Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-α production of oral epithelial cells by areca nut extract and arecoline
نویسندگان
چکیده
Jiiang-Huei Jeng, Ying-Jan Wang, Bor-Luen Chiang, Po-Hsuen Lee, Chiu-Po Chan, Yuan-Soon Ho, Tong-Mei Wang, Jang-Jaer Lee, Liang-Jiunn Hahn, and Mei-Chi Chang 6,7 Laboratory of Dental Pharmacology & Toxicology, Department of Dentistry, National Taiwan University Hospital and National Taiwan University College of Medicine, Graduate Institute of Environmental Medicine, National Cheng-Kung University, Department of Pediatrics, National Taiwan University Hospital and Graduate Institute of Clinical Medicine, National Taiwan University, Department of Dentistry, Chang-Gung Memorial Hospital, Taipei, Department of Biomedical Technology, Taipei Medical College, Team of Biomedical Science, Chang-Gung Institute of Technology, To whom correspondence to be addressed.
منابع مشابه
Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline.
Betel quid (BQ) chewing is an etiologic factor of oral cancer and submucus fibrosis (OSF). Keratinocyte inflammation is crucial for the pathogenesis of cancer and tissue fibrosis. We found that areca nut (AN) extract (100-400 micro g/ml) induced PGE2 production by KB cells by 2.34- to 23.1-fold and also TNF-alpha production by gingival keratinocytes (GK). Arecoline (0.2-1.2 mM) elevated PGE2 pr...
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There are about 600 million people with the betel quid (BQ) chewing habit throughout the world (1). Studies showed that chewing BQ is associated with oral diseases, e.g. oral submucous fibrosis (OSF), oral leukoplakia (OL), and oral cancer (2-5). In addition, the alkaloid extracts from BQ have been characterized as carcinogenic (3-5), immunosuppressive, hepatotoxic (6), immunotoxic (7), genotox...
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Betel quid (BQ) chewing is an etiologic factor of oral submucous fibrosis (OSF) and oral cancer. There are 600 million BQ chewers worldwide. The mechanisms for the toxic and inflammatory responses of BQ are unclear. In this study, both areca nut (AN) extract (ANE) and arecoline stimulated epidermal growth factor (EGF) and interleukin-1α (IL-1α) production of gingival keratinocytes (GKs), wherea...
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Exposure of oral cavity to areca nut is associated with several pathological conditions including oral submucous fibrosis (OSF). Histopathologically OSF is characterized by epithelial atrophy, chronic inflammation, juxtaepithelial hyalinization, leading to fibrosis of submucosal tissue and affects 0.5% of the population in the Indian subcontinent. As the molecular mechanisms leading to atrophie...
متن کاملAreca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential.
There are 600 million betel quid (BQ) chewers in the world. BQ chewing is a major etiologic factor of oral cancer. Areca nut (AN) and arecoline may inhibit the growth of oral mucosal fibroblasts (OMF) and keratinocytes. In this study, AN extract (100-800 microg/ml) and arecoline (20-120 microM) inhibited the growth of oral KB cells by 36-90 and 15-75%, respectively. Exposure to arecoline (> 0.2...
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